Disorders of the Nervous System
Author: María Ximena Silveyra | Email: mxsilveyra@gmail.com
María Ximena Silveyra1°2°, Valentina Filiberti1°2°
1° Instituto de Investigaciones Biológicas (IIB-CONICET-UNMdP)
2° Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata
Oxidative stress is associated with many pathologies, such as neurodegenerative diseases, and polyphenols are antioxidants that could prevent this stress. Potato peel waste (PPW) is an abundant leftover from the potato processing industry. We have previously identified antioxidant polyphenols in PPW ethanolic extracts, such as chlorogenic acid, cafeic acid, and ferulic acid. This study aimed to analyze the neuroprotective effect of PPW on neurodegenerative models and evaluate the mechanisms involved. To test the neuroprotective activity, we assayed subtoxic concentrations of PPW extract in vitro on neuronal HT-22 cells injured by glutamate. First, we demonstrated that pretreatment with these PPW extracts increased cell viability and protected the cells from glutamate-induced apoptosis. Our results showed that PPW polyphenols restored the ∆ѱmit, ROS levels, and lipid peroxidation modified by glutamate in the cellular model. Preliminary, we also demonstrated that the PPW extract pretreatment reduced galactose-induced oxidative stress in an accelerated aging mice model. These findings suggest that PPW extracts have effective neuroprotective properties, demonstrating that they would be a source of neuroprotective compounds to develop a dietary supplement with beneficial effects on human brain health.