Disorders of the Nervous System
Author: Luciana Malvestiti | Email: lucianamalvestiti@gmail.com
Luciana Malvestiti1°2°, Florencia Tano de la Hoz1°,Federico Fioravanti3°, Gabriela Lacconi3°, Silvia Ceré1°, Patricia Setton2°, María Rosa Katunar1°, Vanina Usach2°
1° INTEMA UNMDP- CONICET
2° IQUIFIB UBA-CONICET
3° INFIQC UNC-CONICET
Peripheral nerve injuries affect approximately 1.3 million people worldwide. Those with a gap greater than 5 mm are commonly repaired with a nerve guide conduit, where Mg alloys have emerged as key components for these devices. However, Mg alloys’ main limitation is the fast degradation in aqueous electrolytes, that can be avoided by the development of coatings that enhance their corrosion resistance. Based on the biomedical application, graphene oxide (GO) is a potential coating due to its biocompatibility, good electrical conductivity and its high surface area, however some disadvantages are variations in shapes, sizes and defects on GO structure which could affect the biocompatibility of the Mg alloy. In the present work, bone marrow mononuclear cells (BMMC) obtained from adult rats were seeded on different polished Mg alloy coated with GO to evaluated Mg alloy topography and cell adhesion and viability; a simple drop-immersion method to deposit GO on AZ31 alloy was used. The material characterization revealed the characteristics GO spectra, followed by an enhances in the corrosion resistance. Also, GO coating improves the interaction between the alloy surface and red blood cells, increased BMMC adhesion and Mg-alloy polished promotes cells alignment on the surface. Taking together, these results demonstrate the possibility of GO coating on Mg.