S-124 | Study of changes in brain dynamics during sleep cycles in dogs under the effects of Trazodone.

Theoretical and Computational Neuroscience
Author: Magaly Catanzariti | Email: magalybelenc92@gmail.com

Magaly Catanzariti^1°2°, Alejandra Mondino^3°, Natasha Olby^3°,  Diego Mateos^4°

^1° Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
^2° Instituto de Matemática Aplicada del Litoral (IMAL-CONICET-UNL), CCT CONICET, Santa Fe, Argentina.
^3° Department of Clinical Sciences – North Carolina State University.
^4° Universidad Autonoma de Entre Ríos (Uader), Entre Ríos, Argentina.

Trazodone has been shown to be effective in improving sleep quality in humans. This study aimed to investigate the impact of trazodone on brain dynamics during sleep-wake cycles in healthy dogs, as compared to a control group, using electroencephalographic (EEG) analysis. The signals were stratified into four states: wakefulness, sleepiness, Non-REM, and REM. Power spectral density (PSD) studies were carried out on these signals, as well as non-linear analysis of information and connectivity measures. .
Our findings indicate that 70% of dogs under the influence of trazodone did not enter the Rapid Eye Movement (REM) sleep stage. Additionally, we observed a significant increase in high-frequency brainwave activity during the Non-Rapid Eye Movement (NREM) stage in sedated dogs compared to the control group.
The results provide insights into the effects of trazodone on canine brain activity during sleep, which could have implications for its clinical use as a sleep aid.