Cognition, Behavior, and Memory
Author: Mariana Imperatori | Email: marianaimperatori3@gmail.com
Mariana Imperatori1°, Pedro Bekinschtein1°, Noelia Weisstaub1°
1° Laboratorio de Memoria y Cognición Molecular, Instituto de Neurociencia Cognitiva y Traslacional (CONICET-Fundación INECO-Universidad Favaloro).
Episodic memory can be defined as the memory for unique events. In most situations, reality is ambiguous, and the cues that trigger retrieval are often associated with more than one particular memory. The medial prefrontal cortex (mPFC) controls the retrieval of memory traces, inhibiting the less relevant one, in situations where the cues presented could trigger the expression of more than one and cause interference. We have identified that the mPFC, the ventral hippocampus (vHPC), the dorsal hippocampus (dHPC), as well as the perirhinal cortex (PRH), are involved in the retrieval of memories that integrate more than one type of information. But it is still not known the type of information they store and the interaction among them. We have previously shown that mPFC 5HT2aR are necessary for the control of interference during a contextual version of the object recognition task. However, if and how 5-HT2aR modulation of mPFC subregions are involved in this process is not clear. Combining behavioral and pharmacological tools we started analyzing the contribution of 5-HT2aR within the different subregions of the mPFC in the control of memory interference Our findings show that infralimbic (IL) and prelimbic (PL) 5-HT2aR are required for the retrieval of an object in context memory. Additionally, we have evidence indicating that 5HT2aR modulation of the IL-HPCv; IL-PRH; PL-HPCd and PL-PRH circuits are required during retrieval of this type of memory.