Cognition, Behavior, and Memory
Author: Juan Francisco Robuschi | Email: robuschijuan@gmail.com
Juan Francisco Robuschi1°, Francisco Javier Maza2°,Alejandro Delorenzi1°
1° Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Ciudad Universitaria, Pabellón IFIBYNE, Argentina; Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.
2° Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Ciudad Universitaria, Pabellón IFIBYNE, Argentina.
Predicting whether a particular stressor strengthens or disrupts a specific memory phase is intricate. Unlike theories focused on modulating memory strength, our hypothesis posits that the behavioral expression of reactivated memories is determined, at least in part, by the interplay between reactivated internal states traces (emotions) and mnemonic information when memories are retrieved. There, changes in concurrent internal states form emotional memory traces that will unfold during memory reactivation, modulating expression in evaluation sessions.
In this study, within the aversive memory paradigm of Neohelice, we analyzed behavioral changes during acquisition and retrieval and looked for different internal states’ fingerprints via fluoxetine (SSRI) administration.
Different parameters were evaluated: silhouette displacement (ΔS), average distance traveled per pereopod (ADPP), distance traveled by the body center (DBC), area occupied by the experimental subject for at least 7 seconds (A7s) and differential displacement. Results showed that all parameters indicated changes in activity during the training protocol. Trained animals did not move randomly in the arena. The effect of fluoxetine affected both displacement and spatial aspects.
These parameters allow for not only displacement but also spatial distribution information in this aversive memory paradigm of Neohelice